Institute of Neurological Recovery Blog

Scientific evidence supporting the potential of etanercept to favorably intervene in brain disorders of diverse etiology continues to accrue

Of great interest, independent scientists from around the world continue to provide scientific evidence in basic science models, in addition to the INR’s published clinical studies, supporting the potential of etanercept to favorably intervene in brain disorders of diverse etiology:

1.         Ye, J., R. Jiang, M. Cui, B. Zhu, L. Sun, Y. Wang, A. Zohaib, Q. Dong, X. Ruan, Y. Song, W. He, H. Chen, and S. Cao, Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. J Infect Dis, 2014.

2.         Warrington, J.D., H; Ryan, M; Granger, J, The role of TNF alpha in placental ischemia-induced cerebrovascular abnormalities (1084.6). The FASEB Journal, 2014. 28 no. 1 Supplement 1084.6.

3.         Tobinick, E., H. Rodriguez-Romanacce, A. Levine, T.A. Ignatowski, and R.N. Spengler, Immediate Neurological Recovery Following Perispinal Etanercept Years After Brain Injury. Clin Drug Investig, 2014.

4.         Ekici, M.A., O. Uysal, H.I. Cikriklar, Z. Ozbek, D. Turgut Cosan, C. Baydemir, B. Kazanci, and D. Hafizoglu, Effect of etanercept and lithium chloride on preventing secondary tissue damage in rats with experimental diffuse severe brain injury. Eur Rev Med Pharmacol Sci, 2014. 18(1): p. 10-27.

5.         Chio, C.C., C.H. Chang, C.C. Wang, C.U. Cheong, C.M. Chao, B.C. Cheng, C.Z. Yang, and C.P. Chang, Etanercept attenuates traumatic brain injury in rats by reducing early microglial expression of tumor necrosis factor-alpha. BMC Neurosci, 2013. 14: p. 33.

6.         Cheong, C.U., C.P. Chang, C.M. Chao, B.C. Cheng, C.Z. Yang, and C.C. Chio, Etanercept attenuates traumatic brain injury in rats by reducing brain TNF- alpha contents and by stimulating newly formed neurogenesis. Mediators Inflamm, 2013. 2013: p. 620837.

7.         Boivin, N., R. Menasria, J. Piret, S. Rivest, and G. Boivin, The Combination of Valacyclovir with an Anti-TNF Alpha Antibody [etanercept] Increases Survival Rate Compared to Antiviral Therapy Alone in a Murine Model of Herpes Simplex Virus Encephalitis. Antiviral Res, 2013.

8.         Tobinick, E., N.M. Kim, G. Reyzin, H. Rodriguez-Romanacce, and V. DePuy, Selective TNF inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients treated with perispinal etanercept. CNS Drugs, 2012. 26(12): p. 1051-70.

9.         Tobinick, E., Deciphering the Physiology Underlying the Rapid Clinical Effects of Perispinal Etanercept in Alzheimer’s Disease. Curr Alzheimer Res, 2012. 9(1): p. 99-109.

10.       McAfoose, J., L. Kulic, T. Welt, C. Spani, R. Derungs, A. Pfister, and R. Nitsch, Effects of anti-TNF Therapy on Amyloid Pathology and Neuroinflammation in 12-month old ARCA-beta Transgenic Mice. Alzheimer’s and Dementia, 2012. 8(4): p. P394.

11.       Desjardins, P., T. Du, W. Jiang, L. Peng, and R.F. Butterworth, Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined. Neurochem Int, 2012. 60(7): p. 690-6.

12.       Tobinick, E., Rapid improvement of chronic stroke deficits after perispinal etanercept: three consecutive cases. CNS Drugs, 2011. 25(2): p. 145-55.

13.       Tobinick, E., Perispinal etanercept: a new therapeutic paradigm in neurology. Expert Rev Neurother, 2010. 10(6): p. 985-1002.

14.       Chio, C.C., J.W. Lin, M.W. Chang, C.C. Wang, J.R. Kuo, C.Z. Yang, and C.P. Chang, Therapeutic evaluation of etanercept in a model of traumatic brain injury. J Neurochem, 2010. 115(4): p. 921-9.

15.       Aden, U., G. Favrais, F. Plaisant, M. Winerdal, U. Felderhoff-Mueser, J. Lampa, V. Lelievre, and P. Gressens, Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept. Brain Behav Immun, 2010. 24(5): p. 747-58.

16.       Tobinick, E., Perispinal etanercept for neuroinflammatory disorders. Drug Discov Today, 2009. 14(3-4): p. 168-77.

17.       Tobinick, E., Tumour necrosis factor modulation for treatment of Alzheimer’s disease: rationale and current evidence. CNS Drugs, 2009. 23(9): p. 713-25.

18.       Tobinick, E.L. and H. Gross, Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration. J Neuroinflammation, 2008. 5: p. 2.

19.       Tobinick, E.L. and H. Gross, Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer’s disease. BMC Neurol, 2008. 8: p. 27.

20.       Tobinick, E., H. Gross, A. Weinberger, and H. Cohen, TNF-alpha modulation for treatment of Alzheimer’s disease: a 6-month pilot study. MedGenMed, 2006. 8(2): p. 25.

New study provides further evidence of the central role of TNF in stroke pathophysiology

• A new study, published 14 March 2014, provides further evidence of the central role of TNF in stroke pathobiology:
• “The abstract begins: “Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischaemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumour necrosis factor (TNF), exacerbating tissue damage and worsening the outcomes for stroke patients…..”
• “Our study is in good agreement with other studies pointing to a key role of microglial TNF in early-phase inflammation in the CNS.”

Low, et al., PI3K-delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model, Nature Communications 5, Article number: 3450 doi:10.1038/ncomms4450  Published 14 March 2014.

The full-text and abstract of the study are available at this link:

http://www.nature.com/ncomms/2014/140314/ncomms4450/full/ncomms4450.html

See also: (Tobinick, E., Rapid improvement of chronic stroke deficits after [treatment with a biologic TNF inhibitor]: three consecutive cases. CNS Drugs, 2011. 25(2): p. 145-55; and Tobinick, E., et al., Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury : An Observational Study Involving 629 Consecutive Patients Treated [with a biological TNF inhibitior]. CNS Drugs, 2012. 26(12): p. 1051-70. Results can vary. Please see the Terms of Use.

INR News and Links

For further information regarding the INR, please see the following sources, accessible by clicking on the links below:

• Google Scholar citations to the scientific publications of INR physicians
• The abstract and link to the full text of the published, peer-reviewed article, written by multiple INR physicians, including Nancy Kim MD and Edward Tobinick MD, entitled “Selective TNF Inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients….”
• The abstract and link to the full text of a new scientific, peer-reviewed article that published in 2014, authors Arthur Levine DO*, Helen Rodriguez-Romanacce**, Tracey Ignatowski, Robert Spengler, and Edward Tobinick MD*. *Drs. Levine and Tobinick are physicians on the medical staff of the Institute of Neurological Recovery in Boca Raton, Florida.
• The  abstract and link to the full text (PDF) of the published, peer-reviewed article, entitled “Rapid cognitive improvement in Alzheimer’s disease …“, authored by Edward Tobinick MD and Hyman Gross MD.
• The 60 Minutes Australia 2011 documentary on the INR Alzheimer treatment, entitled “A New Shot at Life“.
• The SunSentinel cover story, entitled “Boca doctor gives stroke survivors new shot at mobility, independence“.
• Edward Tobinick on Linked in
• Edward Tobinick biography
• Edward Tobinick MD Curriculum Vitae as of August 2013

“… a compelling therapeutic strategy to improve neurological outcome in patients after ICH”

Title: TNF-alpha antagonism improves neurological recovery in murine intracerebral hemorrhage

Charlie and Cheryll at the INR Los Angeles July 2013

Charlie and Cheryll Giles with Dr. Tobinick at the INR 100 UCLA Medical Plaza July 11, 2013

Three years after the original filming of “A New Shot at Life” by 60 Minutes Australia.

To view the documentary, please go to the original 60 Minutes Australia feature, available here.