New study provides further evidence of the central role of TNF in stroke pathophysiology

  • A new study, published 14 March 2014, provides further evidence of the central role of TNF in stroke pathobiology:
  • “The abstract begins: “Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischaemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumour necrosis factor (TNF), exacerbating tissue damage and worsening the outcomes for stroke patients…..”
  • “Our study is in good agreement with other studies pointing to a key role of microglial TNF in early-phase inflammation in the CNS.”

Low, et al., PI3K-delta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model, Nature Communications 5, Article number: 3450 doi:10.1038/ncomms4450  Published 14 March 2014.

The full-text and abstract of the study are available at this link:

See also: (Tobinick, E., Rapid improvement of chronic stroke deficits after [treatment with a biologic TNF inhibitor]: three consecutive cases. CNS Drugs, 2011. 25(2): p. 145-55; and Tobinick, E., et al., Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury : An Observational Study Involving 629 Consecutive Patients Treated [with a biological TNF inhibitior]. CNS Drugs, 2012. 26(12): p. 1051-70. Results can vary. Please see the Terms of Use.