Perispinal Etanercept RCT 2019

Gold Coast, Australia (January 3, 2020): The results of a randomized, placebo-controlled, double-blind clinical  trial of perispinal etanercept were published today, confirming the efficacy and remarkable results of perispinal etanercept in a cohort of stroke survivors with relentless, intractable daily pain after stroke. The individuals were treated an average of about 4 years after stroke and each reported constant daily pain after their stroke that had failed to adequately respond to all previous forms of treatment. They received two doses of perispinal etanercept, each two weeks apart, with the control group receiving two doses of saline administered perispinally. The control group had no change in their daily pain, but the etanercept group had a significant reduction in pain, measured at 30 days, with 30% of the etanercept patients showing near complete pain abatement after the first etanercept treatment. The study concludes: “Perispinal etanercept can provide significant and ongoing benefits for the chronic post-stroke management of pain and greater shoulder flexion by the paretic arm. Effects are rapid and highly significant, supporting direct action on brain function.”

The clinical trial results published on January 3, 2020 in the journal  Expert Opinion on Investigational Drugs. Learn More.

Video accompanying the publication, Tobinick E. Immediate Resolution of Hemispatial Neglect and Central Post-Stroke Pain After Perispinal Etanercept: Case Report. Clinical Drug Investigation. 2019. Link to article (open access) and free download

Text, images and video © 2019, Edward Tobinick. Creative Commons license 4.0.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Rapid improvement in speech, chronic central post-stroke pain, and walking 10 years after stroke after perispinal etanercept treatment. Treatment by Edward Tobinick M.D., February 2019, at the INR in Boca Raton, Florida. strokebreakthrough.com 4K version with subtitles. Text, images and video © 2019, INR PLLC, all rights reserved.

Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Rapid improvement in speech, aphasia, motor function and chronic post-stroke pain immediately following perispinal etanercept (PSE) treatment by Edward Tobinick M.D. Filmed January 2019 at the Institute of Neurological Recovery in Boca Raton, Florida. http://www.strokebreakthrough.com 4K version with subtitles. Text, images and video © 2019, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Immediate improvement in chronic post-stroke pain 2 years after stroke. Treatment by Edward Tobinick, filmed November 20, 2018, at the INR in Boca Raton. 4K version, with subtitles. Text, images and video © 2018, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Immediate improvement in central post-stroke pain, 3 years after stroke, following perispinal etanercept. Treatment and filming Oct 31, 2018 and Nov 7, 2018, INR Boca Raton. 4K version, with subtitles. Text, images and video © 2018, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

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Improvement in neurological signs and symptoms of thalamic syndrome (Dejerine-Roussy Syndrome) due to a stroke 20 years previously (in 1998) after treatment at the Institute of Neurological Recovery in Boca Raton in September 2018, by Edward Tobinick, M.D. Text, images and video © 2018, INR PLLC, all rights reserved.

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

Request a consultation today
Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use